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KMID : 1123920120260030301
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Korean Journal of Oriental Physiology and Pathology
2012 Volume.26 No. 3 p.301 ~ p.305
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Effect of Anisi Stellati Fructus Water Extract on Hydrogen Peroxide Production in RAW 264.7 Mouse Macrophages
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Lee Ji-Young
Kim Young-Jin
Kim Hyung-Joo
Lee Min-Woo
Park Wan-Su
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Abstract
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The purpose of this study is to investigate effects of Anisi stellati Fructus Water Extract on hydrogen peroxide production in RAW 264.7 mouse macrophages. Anisi stellati Fructus were extracted by hot water. Effects of Anisi stellati Fructus water extract (AS) on hydrogen peroxide production in RAW 264.7 were measured by dihydrorhodamine 123 assay after 20, 24, 28, 44, 48, and 52 h incubation at the concentrations of 10, 25, 50, and 100 ㎍/mL. For 20 h incubation, AS significantly increased hydrogen peroxide production in RAW 264.7 cells by 108.6 ± 1.56%, 109.5 ± 1.94%, 108.4 ± 1.14%, and 107.3 ± 3.06% at the concentrations of 10, 25, 50, and 100 ㎍/mL (P < 0.05) respectively. For 24, 28, 44, 48, and 52 h incubation, AS also significantly increased hydrogen peroxide production in RAW 264.7 cells at the concentrations of 10, 25, 50, and 100 ㎍/mL (P < 0.05). These results suggest that Anisi stellati Fructus has the immune - enhancing property related with its increase of hydrogen peroxide production in macrophages.
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KEYWORD
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anisi stellati fructus, macrophage, hydrogen peroxide, infection, immunity
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